Low levels of zinc linked with autism in children

via Low levels of zinc linked with autism in children | Mail Online.

Interesting that they say that nothing should be concluded from this. What about concluding that it’s worth testing to see if your asd kid has low zinc? Gasp! What an outrageous thought. How very unseemly to be so forward thinking. You should very well let your children run around with low zinc because low zinc is completely unimportant. As a matter of fact, just stop giving all kids a daily multi-vitamin because we don’t them. Nutrition means nothing. There’s nothing to see here, move along!

Is it really so hard to just say, well, maybe we should look into this? Why is there such a strong need to discredit anything that might support what the crazy autism moms have been saying for decades? Chew on that question for a while.

I think I’m going to start a category of all the stupid shit the media/governments/organizations/etc. say and do to try to prove themselves right while doing their damnedest to make us look bad.

Hypocrites and idiots. Perfect name for it. Look for it on the right.

 

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SYNDROME OF ALLERGY, APRAXIA, AND MALABSORPTION…

Characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation.
http://www.alternative-therapies.com/resources/web_pdfs/recent/0709_morris.pdf

Melatonin Update Breaking Research on the Body’s Master Hormone

By Linda Fugate, PhD

If the body has a master hormone, melatonin may be it. The pineal gland, located in the brain, produces melatonin on a daily schedule. Most melatonin is secreted at night, less in the daytime. This hormone regulates the sleep-wake cycle, (1) as well as the eating cycle (2) and the production of other hormones. (3) Some plants contain melatonin, including several herbs used in Chinese medicine. (4,5,6) Melatonin is well known as a beneficial agent for jet lag and general sleep disturbances, sometimes called delayed sleep phase syndrome. (1) Older people are especially at risk. Approximately 30 percent of people over the age of 50 exhibit insomnia to a greater or lesser degree. However, doses of melatonin as small as 0.3 mg taken at bedtime improves sleep quality. (16) Melatonin provides numerous benefits for both healthy individuals and patients with specific medical conditions. Melatonin production decreases dramatically and predictably with age (Fig. 1).

Melatonin Use in Serious Diseases
Melatonin has been used in the treatment of serious illnesses such as cancer, conditions requiring surgery, schizophrenia with tardive dyskinesia, and blindness with circadian rhythmic disturbances. In addition, daytime sleepiness caused by nighttime sleep disturbances is the greatest identifiable cause of accidents in all modes of transportation. (8)

ICU Psychosis and Melatonin
Surgical patients commonly have their sleep cycle disrupted. (9) The hospital environment may include 24-hour light, noise, unusual activity, needles, tubes, and other disruptions to the patients normal routine. In severe cases, postoperative sleep-wake cycle disruption may result in delirium, which is associated with increased complications and death. The reported incidence of post-operative delirium or confusion is up to 78 percent. Sleep deprivation may even lead to psychosis. Melatonin prevented these postoperative complications in two patients in a preliminary research study at the Albert Einstein College of Medicine in New York. Further research is expected to show benefits for a significant number of patients. (1)

In another study of the effect of premedication with melatonin prior to anesthesia, patients receiving melatonin were found to have less anxiety, better response to anesthesia, and less impairment of cognitive and psychomotor skills. The melatonin doses were administered 100 minutes before standard surgical anesthesia. The optimum dose of melatonin was found to be 0.05 mg per kilogram of body weight. This treatment made the patients feel better while awaiting surgery, and did not impair their recovery. (11) Many other conditions respond to melatonin treatment as well.

Melatonin Aids Cancer Patients Fighting Cachexia
About half of all cancer patients suffer from cachexia, a condition associated with weight loss, psychological distress, and a lower quality of life. Cachexia includes complicated changes in the bodys normal biochemistry. The appetite is suppressed, and the bodys tissues break down in a process called wasting. The wasting process includes increased cytokine production. Cytokines, such as interleukin-1 (IL1), tumor necrosis factor (TNF), and interferons (IFN) can suppress appetite and disturb normal metabolic activity. Other alterations in interwww.y metabolism, including the release of lipid-mobilizing and proteolysis-inducing factors, speed up the loss of body mass.

Appetite is strongly related to the sleep-wake cycle. I discovered this from personal experience on a trip to Germany. My first meal after the flight occurred at approximately 3:00 am in my hometown. I found it difficult to eat when my body thought it was time to sleep. Cancer patients are subject to surgery, sedating drugs, and other medical intervention, sometimes in the middle of the night. Without a normal sleep pattern, they may never feel that its time to wake up and eat. Melatonin treatment can normalize the eating cycle. Additionally, a recent paper reported that melatonin inhibits tumor-derived catabolic factors that produce the wasting effect (cachexia). (2)

Melatonin and Schizophrenia
Schizophrenics also benefit from melatonin. The drugs used to treat schizophrenia may cause tardive dyskinesia, a disabling movement defect. Up to 50 percent of patients hospitalized with schizophrenia suffer from this problem. Tardive dyskinesia is believed to be caused by increased sensitivity of dopamine receptors, plus neurotoxicity caused by oxidative stress. Melatonin has been shown to effectively alleviate these patients symptoms. Researchers in Israel showed that 10 mg per day of melatonin for 6 weeks significantly improved movement control of tardive dyskinesia patients. They attributed these benefits to melatonins antioxidant effects. Melatonin also tends to normalize dopamine release in schizophrenic patients. (12)

Melatonin Improves Quality of Life for Blind People
The quality of life for totally blind people is also improved by melatonin. Most blind people have free-running circadian rhythms that drift away from the normal 24-hour day. Recurrent insomnia and daytime sleepiness may cause significant problems to blind people who already have a difficult life. Melatonin administration can correct the problem in most totally blind people. In a recent study, seven blind people received 10 mg per day of melatonin, one hour before their preferred bedtime. At the beginning of the study, the circadian rhythms of these subjects ranged from 24.2 to 24.9 hours. After three to nine weeks, six of the seven subjects were sleeping on a 24-hour cycle. The dose of melatonin was then reduced to 0.5 mg per day over a period of three months. Once established, the 24-hour cycle persisted even at the much lower dose. (13)

Melatonin and Aging
Aging commonly causes an increase in abdominal fat, plasma insulin, and lipids such as cholesterol. Researchers at the University of Washington showed that melatonin supplements in elderly rats could prevent or even reverse these effects of aging. The melatonin-treated rats also returned to youthful behavior patterns, including response to novelty. (7) In one animal model, melatonin supplements increased the lifespan. Older people are more susceptible to death from infection. Melatonin deficiency is related to decreased immune system function.16 One study showed that melatonin can rejuvenate the degenerative thymus (part of the immune system) in aging animals. (17)

Melatonin plays a direct role in regulating ovarian function. Progesterone production and hormone receptor function were both improved by melatonin. (3) In another study, 2 mg per day of melatonin was useful in balancing the hormones of women 64 to 80 years of age. (18) A decrease in melatonin is also associated with male menopause, also called andropause or androgen decline in the aging male (ADAM). (18)

Melatonin is a Powerful Antioxidant
One important mechanism for melatonins anti-aging effects is its role as an antioxidant. Many researchers believe that antioxidants can prevent and delay the onset of chronic degenerative diseases, and possibly extend the lifespan. Unlike other antioxidants, melatonin reacts with oxidative molecules to produce other molecules which are also antioxidants. This phenomenon is called the free radical scavenging cascade reaction of melatonin. Because of this cascade, one melatonin molecule has the potential to neutralize approximately four reactive oxygenating species. This indicates that melatonin is several times more potent than Vitamin C or Vitamin E as an antioxidant. (19)

Melatonin and Immune System
Melatonin is also a potent stimulator of immune cells, but it should not be taken in combination with Echinacea. Many people take melatonin for sleep disturbances and Echinacea for virus infections, especially in the winter. Canadian researchers tested the effects of the combination of these two products on mice. They found that this combination inhibits the production of granular leukocytes from their precursors, called myeloid cells. Granular leukocytes are important elements of the immune system. Both melatonin and Echinacea stimulate the production of T, B, natural killer cells, and myeloid cells in the immune system, either separately or together. However, melatonin and Echinacea together appear to inhibit the maturation of myeloid cells into granular leukocytes. The exact mechanism for this action is not yet known, but it is not desirable to reduce the granular leukocyte count. (20) Since individual responses to any health product vary, those who respond poorly to Echinacea may want to consider melatonin as an alternative. Melatonin should always be taken near bedtime, even when it is used for purposes other than sleep regulation.

Other Uses for Melatonin
Preliminary research indicates other possible uses. Melatonin has shown some promise as a treatment for migraine headaches. (21) Cluster headaches have also been treated successfully with melatonin. At the Thomas Jefferson University in Philadelphia, two patients were given 9 mg of melatonin daily at bedtime, along with their usual headache medication. Both remained free of headaches during their six to eight month follow-ups. One patient required only two days of melatonin treatment to rid himself of the cluster headaches. (22)

For cancers that are treated with Interleukin-2 immune therapy, the addition of melatonin may prolong survival time and increase the efficiency of Interleukin-2. This strategy appears to be superior to the use of high-dose Interleukin-2 alone. (23)

Agomelatine, which makes melatonin more effective, has been shown to be beneficial in patients with major depression. (25) This result suggests that melatonin itself may be useful in treating depression.

Conclusion
Melatonin is an important hormone that declines with age. People over 50 benefit most from supplemental melatonin, but there are numerous uses for melatonin in people of all ages. The benefits of melatonin include:

Sleep regulation for jet lag, shift work, or general insomnia
Regulation of other hormone cycles
Anti-aging and antioxidant protection
Enhancement of immune function
Better recovery from surgery
Enhancement of cancer therapies
Potential treatment of other diseases, such as tardive dyskinesia and migraine headache

Because of its safety and numerous benefits on health and lifespan, (7,24) I think melatonin may be one of the most effective anti-aging substances currently available.

References:
1. Melatonin Q & A, http://www.vrp.com.

2. Inui A, Cancer anorexia-cachexia syndrome: current issues in research and management, CA Cancer J Clin 2002 Mar-Apr;52(2):72-91.

3. Woo MM, et al. J Clin Endocrinol Metab 2001 Oct;86(10):4789-97.

4. Reiter RJ, Tan DX, Melatonin: an antioxidant in edible plants, Ann N Y Acad Sci 2002 May;957:341-4.

5. Burkhardt S, et al. J Agric Food Chem 2001 Oct;49(10):4898-902.

6. Watanabe H, et al. Am J Chin Med 2002;30(1):65-71.

7. Zhdanova IV, Wurtman RJ, Regan MM, et al, J Clin Endocrinol Metab 2001 Oct;86(10):4727-30.

8. Rasmussen DD, Mitton DR, Larsen SA, Yellon SM. J Pineal Res 2001 Aug;31(1):89-94.

9. Rajaratnam SM, Arendt J, Health in a 24-hour society, Lancet 2001 Sep 22;358(9286):999-1005.

10. Cronin AJ, et al. Lancet 2000 Oct 7;356(9237): 1244-5.

11. Hanania M, Kitain E, Melatonin for treatment and prevention of postoperative delirium, Anesth Analg 2002 Feb;94(2):338-9.

12. Naguib M, Samarkandi AH. Anesth Analg 2000 Aug;92(2):473-9.

13. Atkinson G, Buckley P, Edwards B, Reilly T, Waterhouse J. Int J Sports Med 2001 Apr;22(3):232-4.

14. Shamir E, et al. Arch Gen Psychiatry 2001 Nov;58(11):1054-5.

15. Sack RL, Brandes RW, Kendall AR, Lewy AJ, Entrainment of free-running circadian rhythms by melatonin in blind people, N Engl J Med 2000 Oct12;343(15):1114-6.

16. Karasek M, Reiter RJ, Melatonin and Aging, Neuroendorocrinology Letters 2002;23(Suppl. 1):14-16.

17. Tian YM, et al. J. Pineal Research 2001;31(3):214-221.

18. Pawlikowski M, Kolomecka M, Wojtczak A, Karasek M. Neuroendocrinology Letters 2002;23(Suppl. 1):17-19.

19. Morales A, Heaton JP, Carson CC 3rd, Andropause: a misnomer for a true clinical entity, J Urol 2000 Mar;163(3):705-12.

20. Tan DX, et al. Curr Top Med Chem 2002 Feb;2(2):181-97.

21. Currier NL, Sicotte M, Miller SC. J Leukoc Biol 2001 Aug;70(2):274-6.

22. Gagnier JJ. Altern Med Rev 2001 Aug;6(4):383-9.

23. Melatonin: New Relief from Cluster Headaches? http://www.vrp.com.

24. Lissoni P, Bolis S, Brivio F, Fumagalli L. Anticancer Res 2000 May-Jun;20(3B):2103-5.

25. Skolnick A, Int Clin Psychopharmacol 2002;17:239-247.

26. Medline abstract search, http://www.nlm.nih.gov.

Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation.

Zhang H, Schools GP, Lei T, Wang W, Kimelberg HK, Zhou M.

Neural and Vascular Biology, Ordway Research Institute, Center for
Medical Science, 150 New Scotland Avenue, Albany, NY 12208, USA.

Accumulating evidence indicates that the polyphenol resveratrol
(trans-3, 5, 4″-trihydroxystibene, RVT) potently protects against
cerebral ischemia neuronal damage due to its oxygen free radicals
scavenging and antioxidant properties. However, it is unknown
whether RVT can attenuate ischemia-induced early impairment of
neuronal excitability. To address this question, we simulated
ischemic conditions by applying oxygen-glucose deprivation (OGD) to
acute rat hippocampal slices and examined the effect of RVT on
OGD-induced pyramidal neuron excitability impairment using
whole-cell patch clamp recording. 100 microM RVT largely inhibited
the 15 min OGD-induced progressive membrane potential (Vm)
depolarization and the reduction in evoked action potential
frequency and amplitude in pyramidal neurons. In a parallel neuronal
viability study using TO-PRO-3 iodide staining, 20 min OGD induced
irreversible CA1 pyramidal neuronal death which was significantly
reduced by 100 microM RVT. No similar effects were found with PQQ
treatment, an antioxidant also showing potent neuroprotection in the
rat rMCAO ischemia model. This suggests that antioxidant action per
se, is unlikely accounting for the observed early effects of RVT.
RVT also markedly reduced the frequency and amplitude of AMPA
mediated spontaneous excitatory postsynaptic currents (sEPSCs) in
pyramidal neurons, which is also an early consequence of OGD. RVT
effects on neuronal excitability were inhibited by the
large-conductance potassium channel (BK channel) inhibitor
paxilline. Together, these studies demonstrate that RVT attenuates
OGD-induced neuronal impairment occurring early in the simulated
ischemia slice model by enhancing the activation of BK channel and
reducing the OGD-enhanced AMPA/NMDA receptor mediated neuronal EPSCs.

Are You Being Poisoned? The Danger of Magnesium Stearate and Stearic Acid In Our Health Supplements

By Caroline Cardenas

90% of people who take health supplements are poisoning themselves. How?

If you’ve heard anything about Magnesium Stearate, or Stearic Acid as it is sometimes called, you know that vitamin and supplement bottles everywhere are loaded down with potentially dangerous and life endangering additives that don’t need to be there. The reality is that you probably have not heard of Stearic Acid though and that is a shame, because you are missing key bits of information that can help to save your life.

What is Magnesium Stearate?

Magnesium Stearate is absolutely useless to your body; a metal derivative that your body has absolutely no conceivable use for. Supplement companies have been intentionally misleading their customers for some time now, making it sound like the inclusion of this additive is helpful to your general welfare. The truth is much more frightening and a substantial bit more dangerous.

Magnesium Stearate or Stearic Acid is basically a toxin; a combination of hydrogenated oils that gets into your body and starts killing cells almost immediately. The worst part is that there is Stearic Acid in over 90% of the pills currently on the market. Sometimes it is because of the age of the equipment being used to produce pills; other times it is because supplement companies are trying to milk every last bit of profit out of their machines.

So, how does Magnesium Stearate make its way into your supplements so often? It is a manufacturing tool, used to lubricate the machinery and produce more pills, faster. To be more accurate, Stearic Acid is the byproduct of the hydrogenated oils that are used to lubricate the machinery, having accumulated the metals that saturate these highly dangerous oils. Because they are used to lubricate every aspect of pill production, these hydrogenated oils have saturated every ounce of your supplements, making up as much as 5% of a 1000 mg capsule. Not only does this waste valuable supplement space just so a company can make more pills and more money, it reduces the effectiveness of the pills you are taking.

In addition to weakening your pills, Magnesium Stearate may be loaded with pesticides that are used on the Cottonseed Oil that has been hydrogenated. In addition, with the chemical structure of the fatty acids in Stearic Acid having been altered through close contact with various metal catalysts at extremely high temperatures, the risk of toxicity increases dramatically, introducing countless toxic compounds into your body as a result.

While the companies that produce Vitamins and Supplements may want you to believe that the use of Magnesium Stearate and Stearic Acid in your pills is safe, they are not fooling anyone. You owe it to yourself and your future well being to go to the cupboard right now and remove any pills in there that might contain anything with either of these highly dangerous supplements in them. The market has supported this shoddy, irresponsible production for too long and the health of the industry’s consumers should not need to suffer for it.

Dietary intakes of fat and antioxidant vitamins are predictors of subclinical inflammation in overweight Swiss children

Aeberli I et al.
Am J Clin Nutr. 2006 Oct;84(4):748-55.

BACKGROUND: In obese children, subclinical inflammation is often present
and is correlated with the metabolic syndrome. Dietary factors, such as
fatty acids and antioxidants, potentially modulate the association
between adiposity and subclinical inflammation, but few data are
available in children. OBJECTIVE: The aim of the study was to determine
whether dietary fat or antioxidant intakes influence circulating tumor
necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), C-reactive
protein (CRP), and leptin concentrations in overweight children. DESIGN:
In a cross-sectional study of 6-14-y-old normal-weight (n = 33),
overweight (n = 19), and obese (n = 27) Swiss children, nutritional
intakes were assessed from two 24-h dietary recalls and a 1-d dietary
record. Percentage body fat from skinfold thicknesses, waist-hip ratio,
and blood pressure were measured. Fasting blood samples were collected
for the measurement of insulin, glucose, HDL-cholesterol,
triacylglycerol, CRP, IL-6, TNF-alpha, and leptin concentrations.
RESULTS: CRP, IL-6, and leptin increased significantly (P < 0.02) with
increasing adiposity, independent of age; TNF-alpha did not increase.
Total dietary fat and the percentage of energy from fat were significant
predictors of CRP concentration, independent of body mass index (P <
0.05). Meat intake was a significant predictor of IL-6 and leptin,
independent of body mass index (P < 0.05). Intakes of antioxidant
vitamins (vitamins E and C and beta-carotene) were significant
predictors of leptin (P < 0.05) but not of CRP, IL-6, or TNF-alpha.
CONCLUSIONS: Overweight Swiss children as young as 6 y have elevated
concentrations of inflammatory markers. Intakes of total fat and
antioxidant vitamins are determinants of subclinical inflammation in
this age group.

Big Pharma and the FDA: Suppress the Science and Ban the Natural

From Mercola.com

2005, the pharmaceutical company Biostratum, Inc. made a mistake — they invested millions of dollars into developing a drug, only to discover that the active ingredient, pyridoxamine, was a common, naturally occurring substance that has been sold for decades at low cost.

Biostratum responded by asking the U.S. FDA to declare supplements containing pyridoxamine “adulterated,” and effectively ban anyone but Biostratum from selling pyridoxamine. Earlier this year the FDA agreed to ban companies from selling pyridoxamine as a dietary supplement.

The FDA’s comment on the decision specifically says, “To allow such an article to be marketed as a dietary supplement would not be fair to the pharmaceutical company that brought, or intends to bring, the drug to market.”

Apparently, they were not as concerned about fairness to consumers.

This is hardly the first time the FDA has attacked naturally occurring substances. The FDA has banned information about scientifically proven health benefits of cherries from appearing on Web sites. And for years, the FDA barred health claims about the benefits of omega-3 fats for heart, cancer, depression, body pain, and various other conditions until a drug company paid a great deal of money to go through the approval process.

In the case of pyridoxamine, the FDA did not act out of concern for public safety. This is about a profit-seeking corporation taking advantage of corruption in what is supposed to be a public health organization.

RevitaPOP

Here’s a new product developed by Stan Kurtz and a portion of the proceeds go to Generation Rescue. Yes, I know the pics don’t seem to fit but I’m not so computer savvy that I know how to make them smaller as I just copied and pasted from the site. I’m open to instructions but if you don’t feel like going there with me, you can simply click RevitaPop above and it will take you to the site where you can see the full pictures. Or you can save the pics and view them from your desktop.

ReVitaPop compared to MB12 Injections for Autism

MB12 has been used most often in the subcutaneous injection form (small needles injecting MB12 into body fat).

In the MB12 Parent Group there are polls that show some children respond better to the shots and some children respond better to the the ReVitaPop.

On the Autism Research Institute Parent Report (Form 34) has only collected a small number of reports so far shows a great deal of children with autism respond to MB12 supplementation.

Effects of MB12

Based on video observation and QEEG monitoring, typical effects of MB12 may begin to occur within minutes (sometimes seconds) of the application. An experiment on QEEG activity showed changes almost instantly after MB12 administration. On video, Stan has recorded many subjects feeling better often within minutes and sometimes seconds. Besides autism, which MB12 can have both immediate and long-term benefits, most adults report that any improvements from MB12 occur within the first hour of administration.

The average administration seems to last about 24 hours, but every person is different. Some people that seem to become depleted of MB12 in hours, others seem to feel the benefits for days. Very interestingly, we see reports that for some people the need for MB12 decreases as time goes on. Additionally, the reduction of milk and wheat products, lessening complex carbohydrates and starches and improvements to intestinal flora may decrease the need for MB12. Some people, as in Stan’s case, have reported that their need for MB12 completely diminishes over time.

QEEG Activity

In March of 2006, MB12 was shown to seemingly normalize brain waves of a 23 year old with DSM-IV Attention Deficit Disorder (ADD). Testing included pre testing and 3 post tests including one immediately after administration. All test showed a dramatic lessoning of theta wave activity (3.5-7.5 Hz), which is common in attention challenges, and activity in the entire brain increased, while the subject was observed to be more relaxed and attentive while ocular “twittering” was greatly reduced. A more detailed report of this experiment is available here. This experiment was monitored by Jack Johnstone PhD from Q-Metrx.

University Study of MB12

Stan began meeting with the ADHD research team at UCLA to present his finding on MB12 . After much work, an IRB approved pilot study of MB12. Additionally a study is planned at California State Northridge.

SPECT Activity

In March of 2007, MB12 was shown to seemingly greatly improve brain blood flow of a 53 year old mom of two children with autism and personally struggling with fibromyalgia, depression, and symptoms of brain fog, trouble finding words, memory issues, attention issues and several other chronic symptoms. Along with other possible abnormalities, the baseline test shows a significant amount of hypoprofusion (reduced blood flow) in the temporal, frontal and prefrontal lobes. In the post testing, this individual was sprayed with MB12 50 minutes prior to the SPECT isotope being administered. In addition to the obvious temporal lobe improvement, the frontal lobes dramatically normalized (see the black circle markers on the interactive view). This single person experiment was monitored by J. Michael Uszler M.D. at Santa Monica Imaging.

Anecdotes

In addition to the MB12 recovery videos at www.recoveryvideos.com , there are hundreds of reports on our health web listserve and a short public list as well. Literally tens of thousands of people are reporting on the benefits of supplementing with MB12.

Testimonials

What Experts are saying

Personal Testimonials

Supplements, Supplements, Supplements!

Yes, we can easily drown in the sea of supplements! I know, it’s hard to keep them all straight and it’s hard to afford them all. But here is a list of sources so if you aren’t fortunate enough to live near a great health food store you can still get what you need. I have no affiliation with any of these companies other than as a shopper at a couple. I also don’t hold any back because of bias. To each their own and it’s up to you to decide for yourself.

Kirkman Labs
Nordic Naturals
NCD Zeolites
ASD Market
Millenium Nutritionals
New Beginnings Neutraceuticals
Houston Enzymes
Holistic Heal (Yasko supplements)
The Vitamin Shoppe
Evitamins
Vitacost
Herb Shop
Digestive Wellness (specifically for SCD)
GI Pro Health (specifically for SCD)
NEEDS, Inc.
Enzymedica
Spectrum Mart ASD mom owned, buying groups can be formed.

There are many others and as I either learn of more or remember more I’ll add them.

Happy shopping!

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