An Investigation of Porphyrinuria in Australian Children with Autism

Just a driveby blog to post this:

1: J Toxicol Environ Health A. 2008;71(20):1349-51.

An investigation of porphyrinuria in Australian children with autism.

Austin DW, Shandley K.
Swinburne Autism Bio-Research Initiative (SABRI), Faculty of Life and Social Sciences, Swinburne University of Technology, Melbourne, Australia.

Two recent studies, from France (Nataf et al., 2006) and the United States (Geier & Geier, 2007), identified atypical urinary porphyrin profiles in children with an autism spectrum disorder (ASD). These profiles serve as an indirect measure of environmental toxicity generally, and mercury (Hg) toxicity specifically, with the latter being a variable proposed as a causal mechanism of ASD (Bernard et al., 2001; Mutter et al., 2005). To examine whether this phenomenon occurred in a sample of Australian children with ASD, an analysis of urinary porphyrin profiles was conducted. A consistent trend in abnormal porphyrin levels was evidenced when data was compared with those previously reported in the literature. The results are suggestive of environmental toxic exposure impairing heme synthesis. Three independent studies from three continents have now demonstrated that porphyrinuria is concomitant with ASD, and that Hg may be a likely xenobiotic to produce porphyrin profiles of this nature.

PMID: 18704827


3 Comments (+add yours?)

  1. ~Zurama~
    Jan 31, 2009 @ 22:27:00

    Just dropping by to say hello. You are doing such a good job for all our kids, by telling your son’s story.Keep up the good work!!! 🙂


  2. Cher
    Feb 05, 2009 @ 14:42:00

    Thanks. I know I’ve been super lax on keeping up the blog. I just have so much to do between school and kids and biomed!Hope M’s doing well!


  3. ~Zurama~
    Feb 05, 2009 @ 15:19:00

    He is doing a lot better then a year and a half ago when I started his blog.:D


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